PT  - JOURNAL ARTICLE
AU  - Daniel Paseltiner
AU  - Henry Loeffler
AU  - Alex Andonian
AU  - Abigail Leberman
AU  - Travis J. Gould
AU  - Jason B. Castro
TI  - Spatially organized genomic and physiological heterogeneity of the olfactory bulb mitral cell layer
AID  - 10.1101/2020.01.13.903823
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.01.13.903823
4099  - http://biorxiv.org/content/early/2020/01/14/2020.01.13.903823.short
4100  - http://biorxiv.org/content/early/2020/01/14/2020.01.13.903823.full
AB  - Sensory inputs to the dorsal vs ventral olfactory bulb derive from distinct receptor families, and drive distinct behaviors. To address whether second-order OB neurons and circuits exhibit matching heterogeneity for input-specific readout, we clustered spatial expression profiles of >2,000 genes from the mitral cell layer (MCL). We observed clear dorsal and ventral clusters, together with dorsoventral differences in mitral cell physiology. Bulbar circuits may therefore be tuned for zone-specific computation.