RT Journal Article
SR Electronic
T1 Molecular Choreography of Acute Exercise
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.01.13.905349
DO 10.1101/2020.01.13.905349
A1 Kévin Contrepois
A1 Si Wu
A1 Kegan J Moneghetti
A1 Daniel Hornburg
A1 Sara Ahadi
A1 Ming-Shian Tsai
A1 Ahmed A Metwally
A1 Eric Wei
A1 Brittany Lee-McMullen
A1 Jeniffer V Quijada
A1 Songjie Chen
A1 Jeffrey W Christle
A1 Mathew Ellenberger
A1 Brunilda Balliu
A1 Shalina Taylor
A1 Matthew Durrant
A1 David A Knowles
A1 Hany Choudhry
A1 Melanie Ashland
A1 Amir Bahmani
A1 Brooke Enslen
A1 Myriam Amsallem
A1 Yukari Kobayashi
A1 Monika Avina
A1 Dalia Perelman
A1 Sophia Miryam Schüssler-Fiorenza Rose
A1 Wenyu Zhou
A1 Euan A Ashley
A1 Stephen B Montgomery
A1 Hassan Chaib
A1 Francois Haddad
A1 Michael P. Snyder
YR 2020
UL http://biorxiv.org/content/early/2020/01/14/2020.01.13.905349.abstract
AB Exercise testing is routinely used in clinical practice to assess fitness - a strong predictor of survival - as well as causes of exercise limitations. While these studies often focus on cardiopulmonary response and selected molecular pathways, the dynamic system-wide molecular response to exercise has not been fully characterized. We performed a longitudinal multi-omic profiling of plasma and peripheral blood mononuclear cells including transcriptome, immunome, proteome, metabolome and lipidome in 36 well-characterized volunteers before and after a controlled bout of acute exercise (2, 15, 30 min and 1 hour in recovery). Integrative analysis revealed an orchestrated choreography of biological processes across key tissues. Most of these processes were dampened in insulin resistant participants. Finally, we discovered biological pathways involved in exercise capacity and developed prediction models revealing potential resting blood-based biomarkers of fitness.