TY - JOUR T1 - Functional brain network reconfiguration during learning in a dynamic environment JF - bioRxiv DO - 10.1101/800284 SP - 800284 AU - Chang-Hao Kao AU - Ankit N. Khambhati AU - Danielle S. Bassett AU - Matthew R. Nassar AU - Joseph T. McGuire AU - Joshua I. Gold AU - Joseph W. Kable Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/01/17/800284.abstract N2 - When learning about dynamic and uncertain environments, people should update their beliefs most strongly when new evidence is most informative, such as when the environment undergoes a surprising change or existing beliefs are highly uncertain. Here we show that modulations of surprise and uncertainty are encoded in a particular, temporally dynamic pattern of whole-brain functional connectivity, and this encoding is enhanced in individuals that adapt their learning dynamics more appropriately in response to these factors. The key feature of this whole-brain pattern of functional connectivity is stronger connectivity, or functional integration, between the fronto-parietal and other functional systems. Our results provide new insights regarding the association between dynamic adjustments in learning and dynamic, large-scale changes in functional connectivity across the brain. ER -