PT - JOURNAL ARTICLE AU - Shunchang Jiao AU - Yuxian Bai AU - Chun Dai AU - Xiaoman Xu AU - Xin Cai AU - Guan Wang AU - Jinwang Wei AU - Bing Wu AU - Wending Sun AU - Qiang Xu TI - Application of clinical genomic sequencing among Chinese advanced cancer patients to guide precision medicine decisions AID - 10.1101/367854 DP - 2018 Jan 01 TA - bioRxiv PG - 367854 4099 - http://biorxiv.org/content/early/2018/07/12/367854.short 4100 - http://biorxiv.org/content/early/2018/07/12/367854.full AB - Purpose: A number of studies have suggested that high-throughput genomic analyses might improve the outcomes of cancer patients. However, whether integrative information about genomic sequencing and related clinical interpretation may benefit Chinese cancer patients with stage IV disease to date has not investigated.Methods: Targeted gene panel and whole exome of tumor/blood samples in > 1,000 Chinese cancer patients were sequenced. Then we provided patients and their oncologists with the sequencing results and a clinical recommendation roadmap based on evidence-based medicine, defined as CWES. Only patients with stage IV disease who failed the previous treatment upon receiving the CWES reports were included for analyzing the impact of CWES on clinical outcomes in 1-year follow-ups.Results: We identified the mutational signatures of 953 Chinese cancer patients, with some being unique. Approximately 88.6% of patients had clinically actionable somatic genomic alterations. We successfully followed up 22 stage IV patients. Of these, 11 patients treatment followed the CWES reports defined as group A. Eleven patients received the next treatment, but did not follow the CWES suggestions, and are defined as group B. The types of therapies before CWES were similar in the two groups. The median PFS of group A was 12 months and 45% patients failed this round of therapy. The median PFS of group B was 4 months and 91% of patients failed the treatment.Conclusion: The current study suggested that CWES has the potential to help explore the clinical benefits in multiple line therapies among advanced stage tumor patients.