RT Journal Article
SR Electronic
T1 Genomic and protein structure modelling analysis depicts the origin and infectivity of 2019-nCoV, a new coronavirus which caused a pneumonia outbreak in Wuhan, China
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.01.20.913368
DO 10.1101/2020.01.20.913368
A1 Dong, Ning
A1 Yang, Xuemei
A1 Ye, Lianwei
A1 Chen, Kaichao
A1 Chan, Edward Wai-Chi
A1 Yang, Mengsu
A1 Chen, Sheng
YR 2020
UL http://biorxiv.org/content/early/2020/01/21/2020.01.20.913368.abstract
AB Detailed genomic and structure-based analysis of a new coronavirus, namely 2019-nCoV, showed that the new virus is a new type of bat coronavirus and is genetically fairly distant from the human SARS coronavirus. Structure analysis of the spike (S) protein of this new virus showed that its S protein only binds weakly to the ACE2 receptor on human cells whereas the human SARS coronavirus exhibits strongly affinity to the ACE receptor. These findings suggest that the new virus does not readily transmit between humans and should theoretically not able to cause very serious human infection. These data are important to guide design of infection control policy and inform the public on the nature of threat imposed by 2019-nCov when results of direct laboratory tests on this virus are not expected to be available in the near future.