RT Journal Article
SR Electronic
T1 Human immune system variation during one year
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.01.22.915025
DO 10.1101/2020.01.22.915025
A1 Tadepally Lakshmikanth
A1 Sayyed Auwn Muhammad
A1 Axel Olin
A1 Yang Chen
A1 Jaromir Mikes
A1 Linn Fagerberg
A1 Anders Gummesson
A1 Göran Bergström
A1 Mathias Uhlen
A1 Petter Brodin
YR 2020
UL http://biorxiv.org/content/early/2020/01/23/2020.01.22.915025.abstract
AB The human immune system varies extensively between individuals, but variation within individuals over time has not been well characterized. Systems-level analyses allow for simultaneous quantification of many interacting immune system components, and the inference of global regulatory principles. Here we present a longitudinal, systems-level analysis in 99 healthy adults, 50 to 65 years of age and sampled every 3rd month during one year. We describe the structure of inter-individual variation and characterize extreme phenotypes along a principal curve. From coordinated measurement fluctuations, we infer relationships between 115 immune cell populations and 750 plasma proteins constituting the blood immune system. While most individuals have stable immune systems, the degree of longitudinal variability is an individual feature. The most variable individuals, in the absence of overt infections, exhibited markers of poor metabolic health suggestive of a functional link between metabolic and immunologic homeostatic regulation.HIGHLIGHTS Longitudinal variation in immune cell composition during one yearInter-individual variation can be described along a principal curveImmune cell and protein relationships are inferredVariability over time is an individual feature correlating with markers of poor metabolic health