PT  - JOURNAL ARTICLE
AU  - Justin S Dhindsa
AU  - Angela L McCall
AU  - Laura M Strickland
AU  - Anna F Fusco
AU  - Amanda F Kahn
AU  - Mai K Elmallah
TI  - A motor axonopathy in a mouse model of Duchenne Muscular Dystrophy
AID  - 10.1101/2020.01.22.914614
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.01.22.914614
4099  - http://biorxiv.org/content/early/2020/01/23/2020.01.22.914614.1.short
4100  - http://biorxiv.org/content/early/2020/01/23/2020.01.22.914614.1.full
AB  - Skeletal muscle weakness due to loss of dystrophin is a well-documented pathological hallmark of Duchenne muscular dystrophy (DMD). In contrast, the neuropathology of this disease remains understudied. Here, we characterize an axonopathy in the phrenic and hypoglossal (XII) nerves of mdx mice. We observe nerve dysfunction that we propose contributes to respiratory failure, the most common cause of death in DMD.