PT  - JOURNAL ARTICLE
AU  - Squire, David McG.
AU  - Motyer, Allan
AU  - Ahn, Richard
AU  - Nititham, Joanne
AU  - Huang, Zhi-Ming
AU  - Oksenberg, Jorge R.
AU  - Foerster, John
AU  - Liao, Wilson
AU  - Leslie, Stephen
TI  - MHC*IMP – Imputation of Alleles for Genes in the Major Histocompatibility Complex
AID  - 10.1101/2020.01.24.919191
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.01.24.919191
4099  - http://biorxiv.org/content/early/2020/01/26/2020.01.24.919191.short
4100  - http://biorxiv.org/content/early/2020/01/26/2020.01.24.919191.full
AB  - We report the development of MHC*IMP, a method for imputing non-classical HLA and other genes in the human Major Histocompatibility Complex (MHC). We created a reference panel for 25 genes in the MHC using allele calls from Whole Genome Sequencing data, combined with SNP data for the same individuals. We used this to construct an allele imputation model, MHC*IMP, for each gene. Cross-validation showed that MHC*IMP performs very well, with allele prediction accuracy 93% or greater for all but two of the genes, and greater than 95% for all but four.