RT Journal Article
SR Electronic
T1 MHC*IMP – Imputation of Alleles for Genes in the Major Histocompatibility Complex
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.01.24.919191
DO 10.1101/2020.01.24.919191
A1 David McG. Squire
A1 Allan Motyer
A1 Richard Ahn
A1 Joanne Nititham
A1 Zhi-Ming Huang
A1 Jorge R. Oksenberg
A1 John Foerster
A1 Wilson Liao
A1 Stephen Leslie
YR 2020
UL http://biorxiv.org/content/early/2020/01/26/2020.01.24.919191.abstract
AB We report the development of MHC*IMP, a method for imputing non-classical HLA and other genes in the human Major Histocompatibility Complex (MHC). We created a reference panel for 25 genes in the MHC using allele calls from Whole Genome Sequencing data, combined with SNP data for the same individuals. We used this to construct an allele imputation model, MHC*IMP, for each gene. Cross-validation showed that MHC*IMP performs very well, with allele prediction accuracy 93% or greater for all but two of the genes, and greater than 95% for all but four.