RT Journal Article
SR Electronic
T1 Notorious Novel Avian Influenza Viruses H10N8 and H7N9 in China in 2013 Co-originated from H9N2
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 004390
DO 10.1101/004390
A1 Liang Chen
A1 Feng Zhu
A1 Chenglong Xiong
A1 Zhijie Zhang
A1 Lufang Jiang
A1 Rui Li
A1 Genming Zhao
A1 Yue Chen
A1 Qingwu Jiang
YR 2014
UL http://biorxiv.org/content/early/2014/04/21/004390.abstract
AB In 2013, two new avian influenza viruses (AIVs) H7N9 and H10N8 emerged in China caused worldwide concerns. Previous studies have studied their originations independently; this study is the first time to investigate their co-originating characteristics. Gene segments of assorted subtype influenza A viruses, as well as H10N8 and H7N9, were collected from public database. 26 With the help of series software, small and large-scale phylogenetic trees, mean evolutionary rates, and divergence years were obtained successionally. The results demonstrated the two AIVs co-originated from H9N2, and shared a spectrum of mutations in common on many key sites related to pathogenic, tropism and epidemiological characteristics. For a long time, H9N2 viruses had been circulated in eastern and southern China; poultry was the stable and lasting maintenance reservoir. High carrying rate of AIVs H9N2 in poultry had an extremely high risk of co-infections with other influenza viruses, which increased the risk of virus reassortment. It implied that novel AIVs reassortants based on H9N2 might appear and prevail at any time in China; therefore, surveillance of H9N2 AIVs should be given a high priority.