PT  - JOURNAL ARTICLE
AU  - Ming, Wai-Kit
AU  - Huang, Jian
AU  - Zhang, Casper J. P.
TI  - Breaking down of the healthcare system: Mathematical modelling for controlling the novel coronavirus (2019-nCoV) outbreak in Wuhan, China
AID  - 10.1101/2020.01.27.922443
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.01.27.922443
4099  - http://biorxiv.org/content/early/2020/01/28/2020.01.27.922443.short
4100  - http://biorxiv.org/content/early/2020/01/28/2020.01.27.922443.full
AB  - A novel coronavirus pneumonia initially identified in Wuhan, China and provisionally named 2019-nCoV has surged in the public. In anticipation of substantial burdens on healthcare system following this human-to-human spread, we aim to scrutinise the currently available information and evaluate the burden of healthcare systems during this outbreak in Wuhan. We applied a modified SIR model to project the actual number of infected cases and the specific burdens on isolation wards and intensive care units, given the scenarios of different diagnosis rates as well as different public health intervention efficacy. Our estimates suggest the actual number of infected cases could be much higher than the reported, with estimated 26,701 cases (as of 28th January 2020) assuming 50% diagnosis rate if no public health interventions were implemented. The estimated burdens on healthcare system could be largely reduced if at least 70% efficacy of public health intervention is achieved.