RT Journal Article
SR Electronic
T1 Proteome allocation influences population dynamics in microbial communities
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.01.27.921478
DO 10.1101/2020.01.27.921478
A1 Pacciani-Mori, Leonardo
A1 Giometto, Andrea
A1 Suweis, Samir
A1 Maritan, Amos
YR 2020
UL http://biorxiv.org/content/early/2020/01/28/2020.01.27.921478.abstract
AB Microbial communities are complex systems, and the fundamental mechanisms that control their dynamics and composition are still largely unknown. Here we show that such systems have a previously unexplored level of complexity: their microscopic details related to gene expression influence their macroscopic properties such as the population dynamics. We provide an experimental proof of concept showing that proteome allocation dramatically affects the outcome of competition assays between strains of Escherichia coli. We also provide an essential model that predicts our findings.