RT Journal Article
SR Electronic
T1 Oxytocin modulates the intrinsic dynamics between attention-related large scale networks
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 371971
DO 10.1101/371971
A1 Fei Xin
A1 Feng Zhou
A1 Xinqi Zhou
A1 Xiaole Ma
A1 Yayuan Geng
A1 Weihua Zhao
A1 Shuxia Yao
A1 Debo Dong
A1 Bharat B. Biswal
A1 Keith M. Kendrick
A1 Benjamin Becker
YR 2018
UL http://biorxiv.org/content/early/2018/07/19/371971.abstract
AB Attention and salience processing have been linked to the intrinsic between- and within-network dynamics of large scale networks engaged in internal (default mode network, DN) and external attention allocation (dorsal attention, DAN, salience network, SN). The central oxytocin (OXT) system appears ideally organized to modulate widely distributed neural systems and to regulate the switch between internal attention and salient stimuli in the environment. The current randomized placebo (PLC) controlled between-subject pharmacological resting-state fMRI study in N = 187 (OXT, n = 94; n = 93; single-dose intranasal administration) healthy male and female participants employed an independent component analysis (ICA) approach to determine the modulatory effects of OXT on the within- and between-network dynamics of the DAN-SN-DN triple network system. OXT increased the functional integration between subsystems within SN and DN and increased functional segregation of the DN with the SN and DAN engaged in attentional control. Whereas no sex differences were observed, OXT effects on the DN-SN interaction were modulated by autism traits. Together, the findings suggest that OXT may facilitate efficient attentional allocation towards social cues by modulating the intrinsic functional dynamics between DN components engaged in social processing and large-scale networks involved in external attentional demands (SN, DAN).