PT - JOURNAL ARTICLE AU - Charles N. Serhan AU - Shailendra Gupta AU - Mauro Perretti AU - Catherine Godson AU - Eoin Brennan AU - Yongsheng Li AU - Oliver Soehnlein AU - Takao Shimizu AU - Oliver Werz AU - Valerio Chiurchiù AU - Angelo Azzi AU - Marc Dubourdeau AU - Suchi Smita Gupta AU - Patrick Schopohl AU - Matti Hoch AU - Dragana Gjorgevikj AU - Faiz M. Khan AU - David Brauer AU - Anurag Tripathi AU - Konstantin Cesnulevicius AU - David Lescheid AU - Myron Schultz AU - Dirk Repsilber AU - Robert Kruse AU - Angelo Sala AU - Jesper Z. Haeggström AU - Bruce D. Levy AU - János G. Filep AU - Olaf Wolkenhauer TI - The Atlas of Inflammation-Resolution (AIR) AID - 10.1101/2020.01.27.921882 DP - 2020 Jan 01 TA - bioRxiv PG - 2020.01.27.921882 4099 - http://biorxiv.org/content/early/2020/02/01/2020.01.27.921882.short 4100 - http://biorxiv.org/content/early/2020/02/01/2020.01.27.921882.full AB - Acute inflammation is a protective reaction by the immune system in response to invading pathogens or tissue damage. Ideally, the response should be localized, self-limited, and returning to homeostasis. If not resolved, acute inflammation can result in organ pathologies leading to chronic inflammatory phenotypes. Acute inflammation and inflammation resolution are complex coordinated processes, involving a number of cell types, interacting in space and time. The biomolecular complexity and the fact that several biomedical fields are involved, make a multi and interdisciplinary approach necessary.This Atlas of Inflammation Resolution (AIR) is a web-based resource capturing the state-of-the-art in acute inflammation and inflammation resolution research. The AIR provides an interface for users to search thousands of interactions, arranged in inter-connected multi-layers of process diagrams, covering a wide range of clinically relevant phenotypes. The AIR serves as an open access knowledgebase, including a gateway to numerous public databases. It is furthermore possible for the user to map experimental data onto the molecular interaction maps of the AIR, providing the basis for bioinformatics analyses and systems biology approaches. By mapping experimental data onto the Atlas, it can be used to elucidate drug action as well as molecular mechanisms underlying different disease phenotypes. For the visualization and exploration of information, the AIR uses the Minerva platform, which is a well-established tool for the presentation of disease maps. The molecular details of the AIR are encoded using international standards.The Atlas of Inflammation Resolution was created as a freely accessible resource, supporting research and education in the fields of acute inflammation and inflammation resolution. The AIR connects research communities, facilitates clinical decision making, and supports research scientists in the formulation and validation of hypotheses.AIRAtlas of inflammation resolutionDCDendritic cellILSInnate lymphoid cellsMresResidual macrophageM1M1 macrophageM2M2 macrophageTreg cellRegulatory T cellsPIMPro-inflammatory mediatorsSPMSpecialized pro-resolving lipid mediatorsRvD1Resolvin D1PMNPolymorphonuclear leukocytePAMPsPathogen associated molecular patternsDAMPsDamage associated molecular patternsSBMLSystems biology markup languageMIMMolecular interaction map