PT  - JOURNAL ARTICLE
AU  - Rebecca L. Pfeiffer
AU  - James R. Anderson
AU  - Jeebika Dahal
AU  - Jessica C. Garcia
AU  - Jia-Hui Yang
AU  - Crystal L. Sigulinsky
AU  - Kevin Rapp
AU  - Daniel P. Emrich
AU  - Carl B. Watt
AU  - Hope Morrison
AU  - Alexis R. Houser
AU  - Robert E. Marc
AU  - Bryan W. Jones
TI  - A Pathoconnectome of Early Neurodegeneration
AID  - 10.1101/2020.01.31.929265
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.01.31.929265
4099  - http://biorxiv.org/content/early/2020/02/01/2020.01.31.929265.short
4100  - http://biorxiv.org/content/early/2020/02/01/2020.01.31.929265.full
AB  - Connectomics has demonstrated that synaptic networks and their topologies are precise and directly correlate with physiology and behavior. The next extension of connectomics is pathoconnectomics: to map neural network synaptology and circuit topologies corrupted by neurological disease in order to identify robust targets for therapeutics. In this report, we characterize the first pathoconnectome, in this case, generated from a retina with photoreceptor degeneration. We observe aberrant connectivity in the rod-network pathway and novel synaptic connections deriving from neurite sprouting. These observations reveal principles of neuron responses to the loss of network components and can be extended to other neurodegenerative diseases.