RT Journal Article SR Electronic T1 A Pathoconnectome of Early Neurodegeneration JF bioRxiv FD Cold Spring Harbor Laboratory SP 2020.01.31.929265 DO 10.1101/2020.01.31.929265 A1 Rebecca L. Pfeiffer A1 James R. Anderson A1 Jeebika Dahal A1 Jessica C. Garcia A1 Jia-Hui Yang A1 Crystal L. Sigulinsky A1 Kevin Rapp A1 Daniel P. Emrich A1 Carl B. Watt A1 Hope Morrison A1 Alexis R. Houser A1 Robert E. Marc A1 Bryan W. Jones YR 2020 UL http://biorxiv.org/content/early/2020/02/01/2020.01.31.929265.abstract AB Connectomics has demonstrated that synaptic networks and their topologies are precise and directly correlate with physiology and behavior. The next extension of connectomics is pathoconnectomics: to map neural network synaptology and circuit topologies corrupted by neurological disease in order to identify robust targets for therapeutics. In this report, we characterize the first pathoconnectome, in this case, generated from a retina with photoreceptor degeneration. We observe aberrant connectivity in the rod-network pathway and novel synaptic connections deriving from neurite sprouting. These observations reveal principles of neuron responses to the loss of network components and can be extended to other neurodegenerative diseases.