PT  - JOURNAL ARTICLE
AU  - Greider, Carol W.
TI  - Perspective/Review: Regulating telomere length from the inside out: The replication fork model
AID  - 10.1101/041772
DP  - 2016 Jan 01
TA  - bioRxiv
PG  - 041772
4099  - http://biorxiv.org/content/early/2016/02/29/041772.short
4100  - http://biorxiv.org/content/early/2016/02/29/041772.full
AB  - Telomere length is regulated around an equilibrium set point. Telomeres shorten during replication and are lengthened by telomerase. Disruption of the length equilibrium leads to disease, thus it is important to understand the mechanisms that regulate length at the molecular level. The prevailing protein counting model for regulating telomerase access to elongate the telomere does not explain accumulating evidence of a role of DNA replication in telomere length regulation. Here I present an alternative model: the replication fork model that can explain how passage of a replication fork and regulation of origin firing affect telomere length.