PT  - JOURNAL ARTICLE
AU  - Hisashi Sawada
AU  - Hideyuki Higashi
AU  - Debra L. Rateri
AU  - Jeff Z. Chen
AU  - Jessica J. Moorleghen
AU  - Deborah A. Howatt
AU  - Hong S. Lu
AU  - Stephanie Morgan
AU  - Sasha A. Singh
AU  - Masanori Aikawa
AU  - Mark W. Majesky
AU  - Alan Daugherty
TI  - Functional Importance of Second Heart Field-derived Cells During Thoracic Aortic Aneurysm Formation
AID  - 10.1101/2020.02.02.930917
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.02.02.930917
4099  - http://biorxiv.org/content/early/2020/02/02/2020.02.02.930917.short
4100  - http://biorxiv.org/content/early/2020/02/02/2020.02.02.930917.full
AB  - Embryonic origins of smooth muscle cells (SMCs) may contribute to regional specificity of thoracic aortic aneurysms. Here, we demonstrate that SMCs derived from the second heart field localized with angiotensin II-induced aortopathies. Proteomics analysis discerned potential roles of Lrp1 and TGF-β pathways, and genetic ablation of these pathways in second heart field-derived cells augmented aortopathies, indicating functional importance of this origin on aortic integrity.