RT Journal Article
SR Electronic
T1 A large cross-ancestry meta-analysis of genome-wide association studies identifies 69 novel risk loci for primary open-angle glaucoma and includes a genetic link with Alzheimer’s disease
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.01.30.927822
DO 10.1101/2020.01.30.927822
A1 Puya Gharahkhani
A1 Eric Jorgenson
A1 Pirro Hysi
A1 Anthony P. Khawaja
A1 Sarah Pendergrass
A1 Xikun Han
A1 Jue Sheng Ong
A1 Alex W. Hewitt
A1 Ayellet Segre
A1 Robert P. Igo, Jr
A1 Helene Choquet
A1 Ayub Qassim
A1 Navya S Josyula
A1 Jessica N. Cooke Bailey
A1 Pieter Bonnemaijer
A1 Adriana Iglesias
A1 Owen M. Siggs
A1 Terri Young
A1 Veronique Vitart
A1 Alberta A.H.J. Thiadens
A1 Juha Karjalainen
A1 Steffen Uebe
A1 Ronald B. Melles
A1 K. Saidas Nair
A1 Robert Luben
A1 Mark Simcoe
A1 Nishani Amersinghe
A1 Angela J. Cree
A1 Rene Hohn
A1 Alicia Poplawski
A1 Li Jia Chen (CUHK)
A1 Ching-Yu Cheng
A1 Eranga Nishanthie Vithana
A1 NEIGHBORHOOD consortium
A1 ANZRAG consortium
A1 Biobank Japan project
A1 FinnGen study
A1 UK Biobank Eye and Vision Consortium
A1 GIGA study group
A1 23andMe Research Team
A1 Gen Tamiya
A1 Yukihiro Shiga
A1 Masayuki Yamamoto
A1 Toru Nakazawa
A1 John Rouhana
A1 Hannah Currant
A1 Ewan Birney
A1 Xin Wang
A1 Adam Auton
A1 Adeyinka Ashaye
A1 Olusola Olawoye
A1 Susan E. Williams
A1 Stephen Akafo
A1 Michele Ramsay
A1 Kazuki Hashimoto
A1 Yoichito Kamatani
A1 Masato Akiama
A1 Yukihide Momozawa
A1 Paul J. Foster
A1 Peng T. Khaw
A1 James E. Morgan
A1 Nicholas G. Strouthidis
A1 Peter Kraft
A1 Jae Hee Kang
A1 Calvin Chi Pui Pang (CUHK)
A1 Francesca Pasutto
A1 Paul Mitchell
A1 Andrew J. Lotery
A1 Aarno Palotie
A1 Cornelia van Duijn
A1 Jonathan Haines
A1 Chris Hammond
A1 Louis R. Pasquale
A1 Caroline C.W. Klaver
A1 Michael Hauser
A1 Chiea Chuen Khor
A1 David A. Mackey
A1 Michiaki Kubo
A1 Tin Aung
A1 Jamie Craig
A1 Stuart MacGregor
A1 Janey Wiggs
YR 2020
UL http://biorxiv.org/content/early/2020/02/03/2020.01.30.927822.abstract
AB We conducted a large multi-ethnic meta-analysis of genome-wide association studies for primary open-angle glaucoma (POAG) on a total of 34,179 cases vs 349,321 controls, and identified 127 independent risk loci, almost doubling the number of known loci for POAG. The majority of loci have broadly consistent effect across European, Asian and African ancestries. We identify a link, both genome-wide and at specific loci, between POAG and Alzheimer’s disease. Gene expression data and bioinformatic functional analyses provide further support for the functional relevance of the POAG risk genes. Several drug compounds target these risk genes and may be potential candidates for developing novel POAG treatments.