@article {Garin2020.02.03.931626, author = {Vincent Garin and Marcos Malosetti and Fred van Eeuwijk}, title = {The usefulness of multi-parent multi-environment QTL analysis: an illustration in different NAM populations}, elocation-id = {2020.02.03.931626}, year = {2020}, doi = {10.1101/2020.02.03.931626}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Commonly QTL detection in multi-parent population (MPPs) data measured in multiple environments (ME) is done by a single environment analysis on phenotypic values {\textquoteleft}averaged{\textquoteright} across environments. This method can be useful to detect QTLs with a consistent effect across environments but it does not allow to estimate environment-specific QTL (QTLxE) effects. Running separate single environment analyses is a possibility to measure QTLxE effects but those analyses do not model the genetic covariance due to the use of the same genotype in different environments. In this paper, we propose methods to analyze MPP-ME QTL experiments using simultaneously the data from several environments and modelling the genotypic covariances. Using data from the EU-NAM and the US-NAM populations, we show that these methods allow to estimate the QTLxE effects and that they give a more precise description of the trait genetic architecture than separate within environment analyses. The MPP-ME models we propose can also be extended to integrate environmental indices (e.g. temperature, precipitation, etc.) to understand better the mechanisms behind the QTLxE effects. Therefore, our methodology allows to exploit the full potential of MPP-ME data: to estimate QTL effect variations a) within the MPP between sub-populations due to different genetic backgrounds; and b) between environments.}, URL = {https://www.biorxiv.org/content/early/2020/02/03/2020.02.03.931626}, eprint = {https://www.biorxiv.org/content/early/2020/02/03/2020.02.03.931626.full.pdf}, journal = {bioRxiv} }