PT - JOURNAL ARTICLE AU - Shreyas Mahapatra AU - Edward Khokhlovich AU - Samantha Martinez AU - Benjamin Kannel AU - Stephen M Edelson AU - Andrey Vyshedskiy TI - Longitudinal Epidemiological Study of Autism Subgroups Using Autism Treatment Evaluation Checklist (ATEC) Score AID - 10.1101/266221 DP - 2018 Jan 01 TA - bioRxiv PG - 266221 4099 - http://biorxiv.org/content/early/2018/07/23/266221.short 4100 - http://biorxiv.org/content/early/2018/07/23/266221.full AB - Here we report the results of the subgroup analyses of an observational cohort of children whose parents completed the Autism Treatment Evaluation Checklist (ATEC) over the period of several years. A linear mixed effects model was used to evaluate longitudinal changes in ATEC scores within different patient subgroups. All groups decreased their mean ATEC score over time indicating improvement of symptoms, however there were significant differences between the groups. Younger children improved more than the older children. Children with milder ASD improved more than children with more severe ASD in the Communication subscale. There was no difference in improvement between females vs. males. One surprising finding was that children from developed English-speaking countries improved less than children from non-English-speaking countries.