RT Journal Article
SR Electronic
T1 Longitudinal Epidemiological Study of Autism Subgroups Using Autism Treatment Evaluation Checklist (ATEC) Score
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 266221
DO 10.1101/266221
A1 Shreyas Mahapatra
A1 Edward Khokhlovich
A1 Samantha Martinez
A1 Benjamin Kannel
A1 Stephen M Edelson
A1 Andrey Vyshedskiy
YR 2018
UL http://biorxiv.org/content/early/2018/07/23/266221.abstract
AB Here we report the results of the subgroup analyses of an observational cohort of children whose parents completed the Autism Treatment Evaluation Checklist (ATEC) over the period of several years. A linear mixed effects model was used to evaluate longitudinal changes in ATEC scores within different patient subgroups. All groups decreased their mean ATEC score over time indicating improvement of symptoms, however there were significant differences between the groups. Younger children improved more than the older children. Children with milder ASD improved more than children with more severe ASD in the Communication subscale. There was no difference in improvement between females vs. males. One surprising finding was that children from developed English-speaking countries improved less than children from non-English-speaking countries.