PT  - JOURNAL ARTICLE
AU  - Claudia Compagnucci
AU  - Michael J. Depew
TI  - <em>Foxg1</em> Organizes Cephalic Ectoderm to Repress Mandibular Fate, Regulate Apoptosis, Generate Choanae, Elaborate the Auxiliary Eye and Pattern the Upper Jaw
AID  - 10.1101/2020.02.05.935189
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.02.05.935189
4099  - http://biorxiv.org/content/early/2020/02/05/2020.02.05.935189.short
4100  - http://biorxiv.org/content/early/2020/02/05/2020.02.05.935189.full
AB  - Gnathostome jaw patterning involves focal instructive signals from the embryonic surface cephalic ectoderm (SCE) to a fungible population of cranial neural crest. The spatial refinement of these signals, particularly for those patterning the upper jaws, is not fully understood. We demonstrate that Foxg1, broadly expressed in the SCE overlying the upper jaw primordia, is required for both neurocranial and viscerocranial development, including the sensory capsules, neurocranial base, middle ear, and upper jaws. Foxg1 controls upper jaw molecular identity and morphologic development by actively inhibiting the inappropriate acquisition of lower jaw molecular identity within the upper jaw primordia, and is necessary for the appropriate elaboration of the λ-junction, choanae, palate, vibrissae, rhinarium, upper lip and auxiliary eye. It regulates intra-epithelial cellular organization, gene expression, and the topography of apoptosis within the SCE. Foxg1 integrates forebrain and skull development and genetically interacts with Dlx5 to establish a single, rostral cranial midline.