RT Journal Article SR Electronic T1 Quantitative interactions drive Botrytis cinerea disease outcome across the plant kingdom JF bioRxiv FD Cold Spring Harbor Laboratory SP 507491 DO 10.1101/507491 A1 Celine Caseys A1 Gongjun Shi A1 Nicole Soltis A1 Raoni Gwinner A1 Jason Corwin A1 Susanna Atwell A1 Daniel Kliebenstein YR 2020 UL http://biorxiv.org/content/early/2020/02/06/507491.abstract AB Botrytis cinerea is a polyphagous fungal pathogen that causes necrotic disease on more than a thousand known hosts widely spread across the plant kingdom. While it is known that quantitative resistance in the host and quantitative virulence in the pathogen largely mediate this pathosystem, how this pathogen interacts with the extensive host diversity is unknown. Does this pathogen have quantitative virulence efficiency on all hosts or individual solutions for each host? To address this question, we generated an infectivity matrix of 98 strains of Botrytis cinerea on 90 genotypes representing eight host plants. This experimental infectivity matrix showed that the predominant sources of quantitative variation are between host species and among pathogen strains. Furthermore, the eight eudicot hosts interacted individually with Botrytis cinerea strains independently of the evolutionary relatedness between hosts. An additive quantitative model can explain the complexity of these interactions in which Botrytis host specificity and general virulence have distinct polygenic architectures.