RT Journal Article
SR Electronic
T1 Substantia nigra dopamine neurons evoke a delayed excitation in lateral dorsal striatal cholinergic interneurons via glutamate cotransmission
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 377150
DO 10.1101/377150
A1 Nao Chuhma
A1 Susana Mingote
A1 Leora Yetnikoff
A1 Abigail Kalmbach
A1 Thong Ma
A1 Samira Ztaou
A1 Anna-Claire Siena
A1 Sophia Tepler
A1 Jean-Francois Poulin
A1 Mark Ansorge
A1 Rajeshwar Awatramani
A1 Un Jung Kang
A1 Stephen Rayport
YR 2018
UL http://biorxiv.org/content/early/2018/07/25/377150.abstract
AB Dopamine neurons have different synaptic actions in the ventral and dorsal striatum (dStr), but whether this heterogeneity extends to dStr subregions has not been addressed. We have found that optogenetic activation of dStr dopamine neuron terminals in mouse brain slices pauses the firing of cholinergic interneurons in both the medial and lateral subregions, while in the lateral subregion the pause is shorter due to a subsequent excitation. This excitation is mediated mainly by metabotropic glutamate receptor 1 (mGluR1) and partially by dopamine D1-like receptors coupled to transient receptor potential channel 3 and 7. DA neurons do not signal to spiny projection neurons in the medial dStr, while they elicit ionotropic glutamate responses in the lateral dStr. The DA neurons mediating these excitatory signals are in the substantia nigra (SN). Thus, SN dopamine neurons engage different receptors in different postsynaptic neurons in different dStr subregions to convey strikingly different signals.