PT  - JOURNAL ARTICLE
AU  - Schaum, Michael
AU  - Pinzuti, Edoardo
AU  - Sebastian, Alexandra
AU  - Lieb, Klaus
AU  - Fries, Pascal
AU  - Mobascher, Arian
AU  - Jung, Patrick
AU  - Wibral, Michael
AU  - Tüscher, Oliver
TI  - Cortical network mechanisms of response inhibition
AID  - 10.1101/2020.02.09.940841
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.02.09.940841
4099  - http://biorxiv.org/content/early/2020/02/10/2020.02.09.940841.short
4100  - http://biorxiv.org/content/early/2020/02/10/2020.02.09.940841.full
AB  - Both the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (pre-SMA) are crucial for successful response inhibition. However, the particular functional roles of those two regions have been controversially debated for more than a decade now. It is unclear whether the rIFG directly initiates stopping or serves an attentional function, whereas the stopping is triggered by the pre-SMA. The current multimodal MEG/fMRI study sought to clarify the role and temporal activation order of both regions in response inhibition using a selective stopping task. This task dissociates inhibitory from attentional processes. Our results reliably reveal a temporal precedence of rIFG over pre-SMA. Moreover, connectivity during response inhibition is directed from rIFG to pre-SMA and predicts stopping performance. Response inhibition is implemented via beta-band oscillations. Our findings support the hypothesis that response inhibition is initiated by the rIFG as a form of attention-independent top-down control.