RT Journal Article
SR Electronic
T1 Cortical network mechanisms of response inhibition
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.02.09.940841
DO 10.1101/2020.02.09.940841
A1 Schaum, Michael
A1 Pinzuti, Edoardo
A1 Sebastian, Alexandra
A1 Lieb, Klaus
A1 Fries, Pascal
A1 Mobascher, Arian
A1 Jung, Patrick
A1 Wibral, Michael
A1 Tüscher, Oliver
YR 2020
UL http://biorxiv.org/content/early/2020/02/10/2020.02.09.940841.abstract
AB Both the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (pre-SMA) are crucial for successful response inhibition. However, the particular functional roles of those two regions have been controversially debated for more than a decade now. It is unclear whether the rIFG directly initiates stopping or serves an attentional function, whereas the stopping is triggered by the pre-SMA. The current multimodal MEG/fMRI study sought to clarify the role and temporal activation order of both regions in response inhibition using a selective stopping task. This task dissociates inhibitory from attentional processes. Our results reliably reveal a temporal precedence of rIFG over pre-SMA. Moreover, connectivity during response inhibition is directed from rIFG to pre-SMA and predicts stopping performance. Response inhibition is implemented via beta-band oscillations. Our findings support the hypothesis that response inhibition is initiated by the rIFG as a form of attention-independent top-down control.