TY - JOUR T1 - Association of gut microbiota with metabolism in juvenile Atlantic Salmon JF - bioRxiv DO - 10.1101/2020.02.10.941245 SP - 2020.02.10.941245 AU - H. Dvergedal AU - S.R. Sandve AU - I.L. Angell AU - G. Klemetsdal AU - K. Rudi Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/02/10/2020.02.10.941245.abstract N2 - The gut microbiome plays a key role in animal health and metabolism through the intricate functional interconnection between the feed, gut microbes, and the host. Unfortunately, in aquaculture, the links between gut microbes and fish genetics and production phenotypes are not well understood.In this study, we investigate the associations between gut microbial communities, fish feed conversion, and fish genetics in the domestic Atlantic salmon. Microbial community composition was determined for 230 juvenile fish from 23 full-sib families and was then regressed on growth, carbon and nitrogen metabolism, and feed efficiency. We only found weak associations between host genetics and microbial composition. However, we did identify significant (p < 0.05) associations between the abundance of three microbial operational taxonomical units (OTUs) and fish metabolism phenotypes. Two OTUs were associated with both carbon metabolism in adipose tissue and feed efficiency, while a third OTU was associated with weight gain.In conclusion, this study demonstrates an intriguing association between host lipid metabolism and the gut microbiota composition in Atlantic salmon. ER -