RT Journal Article
SR Electronic
T1 The network structure and eco-evolutionary dynamics of CRISPR-induced immune diversification
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 850800
DO 10.1101/850800
A1 Shai Pilosof
A1 Sergio A. Alcala-Corona
A1 Tong Wang
A1 Ted Kim
A1 Sergei Maslov
A1 Rachel Whitaker
A1 Mercedes Pascual
YR 2020
UL http://biorxiv.org/content/early/2020/02/12/850800.abstract
AB As a heritable sequence-specific adaptive immune system, CRISPR-Cas is a powerful force shaping strain diversity in host-virus systems. While the diversity of CRISPR alleles has been explored, the associated structure and dynamics of host-virus interactions has not. We develop theory on the role of CRISPR immunity in mediating the interplay between host-virus interaction structure and eco-evolutionary dynamics in a computational model and three natural systems. We show that the structures of networks describing who infects whom and who is protected from whom are modular and weighted-nested, respectively. The dynamic interplay between these networks influences transitions between dynamical regimes of virus diversification and host control, leading to eventual virus extinction. The three empirical systems exhibit weighted nestedness, a pattern our theory shows is indicative of viral control by hosts. Previously missing from studies of microbial host-pathogen systems, the protection network plays a key role in the coevolutionary dynamics.