PT  - JOURNAL ARTICLE
AU  - Ofer Kimchi
AU  - Carl P. Goodrich
AU  - Alexis Courbet
AU  - Agnese I. Curatolo
AU  - Nicholas B. Woodall
AU  - David Baker
AU  - Michael P. Brenner
TI  - Self-assembly based post-translational protein oscillators
AID  - 10.1101/2020.02.12.946145
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.02.12.946145
4099  - http://biorxiv.org/content/early/2020/02/13/2020.02.12.946145.short
4100  - http://biorxiv.org/content/early/2020/02/13/2020.02.12.946145.full
AB  - Recent advances in synthetic post-translational protein circuits are significantly impacting the landscape of biomimicry engineering. However, designing sustained dynamic phenomena in these circuits remains an outstanding challenge. Inspired by the KaiABC system regulating the circadian clock in cyanobacteria, we develop two experimentally realizable post-translational oscillators. The oscillators rely on a small number of components interacting only through reversible binding and phosphorylation/dephosphorylation reactions.