TY - JOUR T1 - Chronic wireless streaming of invasive neural recordings at home for circuit discovery and adaptive stimulation JF - bioRxiv DO - 10.1101/2020.02.13.948349 SP - 2020.02.13.948349 AU - Ro’ee Gilron AU - Simon Little AU - Randy Perrone AU - Robert Wilt AU - Coralie de Hemptinne AU - Maria S. Yaroshinsky AU - Caroline A. Racine AU - Sarah Wang AU - Jill L. Ostrem AU - Paul S. Larson AU - Doris D. Wang AU - Nick B. Galifianakis AU - Ian Bledsoe AU - Marta San Luciano AU - Heather E. Dawes AU - Gregory A. Worrell AU - Vaclav Kremen AU - David Borton AU - Timothy Denison AU - Philip A. Starr Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/02/14/2020.02.13.948349.abstract N2 - Invasive neural recording in humans shows promise for understanding the circuit basis of brain disorders. Most recordings have been done for short durations from externalized brain leads in hospital settings, or from first-generation implantable sensing devices that offer only intermittent brief streaming of time series data. Here we report the first human use of an implantable neural interface for wireless multichannel streaming of field potentials over long periods, with and without simultaneous therapeutic neurostimulation, untethered to receiving devices. Four Parkinson’s disease patients streamed bilateral 4-channel motor cortical and basal ganglia field potentials at home for over 500 hours, paired with wearable monitors that behaviorally categorize states of inadequate or excessive movement. Motor state during normal home activities was efficiently decoded using either supervised learning or unsupervised clustering algorithms. This platform supports adaptive deep brain stimulation, and may be widely applicable to brain disorders treatable by invasive neuromodulation. ER -