RT Journal Article
SR Electronic
T1 Sex moderates the relationship between aortic stiffness, cognition and cerebrovascular reactivity in healthy older adults
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.02.18.955146
DO 10.1101/2020.02.18.955146
A1 Dalia Sabra
A1 Brittany Intzandt
A1 Laurence Desjardins-Crepeau
A1 Antoine Langeard
A1 Christopher J. Steele
A1 Frédérique Frouin
A1 Richard D. Hoge
A1 Louis Bherer
A1 Claudine J. Gauthier
YR 2020
UL http://biorxiv.org/content/early/2020/02/19/2020.02.18.955146.abstract
AB It is well established that sex differences exist in the manifestation of cardiovascular diseases. Arterial stiffness (AS) has been associated with changes in cerebrovascular reactivity (CVR) and cognitive decline in aging. Specifically, older adults with increased AS show a decline on executive function (EF) tasks. Interestingly, the relationship between AS and CVR is more complex, where some studies show decreased CVR with increased AS, and others demonstrate preserved CVR despite higher AS. We investigated the possible role of sex and hematocrit (HCT) on these hemodynamic relationships. Acquisitions were completed in 48 older adults. Dual-echo pCASL data were collected during a hypercapnia challenge. Aortic PWV data was acquired using cine phase contrast velocity series. A moderation model test revealed that sex moderated the relationship between PWV and CVR and PWV and EF. In addition, there was a significant effect of HCT on the sex differences observed in the moderation effect on EF. Together, our results indicate that the relationships between PWV, CVR and EF are in part mediated by sex and HCT.HighlightsThis study investigates the role of sex on cerebrovascular measures of brain health and congitionSex moderates the relationship between PWV, cerebrovascular reactivity and cognitionHematocrit influences the sex differences observedCVDCardiovascular diseaseMRIMagnetic resonance imagingASLArterial spin labellingPWVPulse wave velocityCVRCerebrovascular reactivityHGBHemoglobinHCTHematocritCSFCerebrospinal fluidVBMVoxel based morphometryPPPulse pressureASArterial stiffnessCBFCerebral blood flowEFExecutive functionPETPositron-emission tomographyTCDTranscranial dopplerPSProcessing speedMMSEMini-mental state examinationCWITColor-word interference testTMT-BTrail making test part BSNRSignal-to-noise ratioWMHWhite matter hyperintensitiespCASLPseudo-continuous arterial spin labelingFLAIRFluid-attenuated inversion recoveryNONitric oxide