TY - JOUR T1 - Immunological role of primary cilia of dendritic cells in human skin disease JF - bioRxiv DO - 10.1101/2020.02.04.933333 SP - 2020.02.04.933333 AU - Manami Toriyama AU - Defri Rizaldy AU - Motoki Nakamura AU - Fumitaka Fujita AU - Fumihiro Okada AU - Akimichi Morita AU - Ken J. Ishii Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/02/20/2020.02.04.933333.abstract N2 - Primary cilia are a unique organelle, known to provide a signaling hub for variety of cell activities. Their potential role(s) in human immune homeostasis and diseases, however, have yet to be explored. Here, we show that human dendritic cells (DCs) express primary cilia-like structure. The primary cilia growth during DC proliferation by GM-CSF was shut off by DC maturation agents, suggesting the role of primary cilia to transduce proliferation signaling. PDGFRα pathway, one of proliferation signal in primary cilia, promoted DC proliferation in a dependent manner of intra-flagellar transport system. In epidermis with atopic dermatitis patients, aberrant ciliated langerhans cells and keratinocytes with showing immature state were observed that may play a potential role in inflammation and skin barrier disorder. ER -