PT  - JOURNAL ARTICLE
AU  - Chen, Yiyou
AU  - Wei, Qiang
AU  - Li, Ruobing
AU  - Gao, Hong
AU  - Zhu, Hua
AU  - Deng, Wei
AU  - Bao, Linlin
AU  - Tong, Wei
AU  - Cong, Zhe
AU  - Jiang, Hong
AU  - Qin, Chuan
TI  - Protection of Rhesus Macaque from SARS-Coronavirus challenge by recombinant adenovirus vaccine
AID  - 10.1101/2020.02.17.951939
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.02.17.951939
4099  - http://biorxiv.org/content/early/2020/02/21/2020.02.17.951939.short
4100  - http://biorxiv.org/content/early/2020/02/21/2020.02.17.951939.full
AB  - A recombinant adenovirus vaccine against the SARS Coronavirus (SARS-CoV) was constructed, which contains fragments from the S, N, and Orf8 genes. Rhesus Macaques immunized with the recombinant adenovirus generated antigen-specific humoral and cellular response. Furthermore, the vaccine provided significant protection against subsequent live SARS-CoV challenge. In contrast, three out of four monkeys immunized with placebo suffered severe alveolar damage and pulmonary destruction.