RT Journal Article
SR Electronic
T1 Protection of Rhesus Macaque from SARS-Coronavirus challenge by recombinant adenovirus vaccine
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.02.17.951939
DO 10.1101/2020.02.17.951939
A1 Chen, Yiyou
A1 Wei, Qiang
A1 Li, Ruobing
A1 Gao, Hong
A1 Zhu, Hua
A1 Deng, Wei
A1 Bao, Linlin
A1 Tong, Wei
A1 Cong, Zhe
A1 Jiang, Hong
A1 Qin, Chuan
YR 2020
UL http://biorxiv.org/content/early/2020/02/21/2020.02.17.951939.abstract
AB A recombinant adenovirus vaccine against the SARS Coronavirus (SARS-CoV) was constructed, which contains fragments from the S, N, and Orf8 genes. Rhesus Macaques immunized with the recombinant adenovirus generated antigen-specific humoral and cellular response. Furthermore, the vaccine provided significant protection against subsequent live SARS-CoV challenge. In contrast, three out of four monkeys immunized with placebo suffered severe alveolar damage and pulmonary destruction.