RT Journal Article SR Electronic T1 A neutrophil-driven inflammatory signature characterizes the blood cell transcriptome fingerprints of Psoriasis and Kawasaki Disease JF bioRxiv FD Cold Spring Harbor Laboratory SP 2020.02.24.962621 DO 10.1101/2020.02.24.962621 A1 Arun Rawat A1 Darawan Rinchai A1 Mohammed Toufiq A1 Alexandra Marr A1 Tomoshige Kino A1 Mathieu Garand A1 Mohammed Yousuf Karim A1 Seetharama Sastry A1 Aouatef Chouchane A1 Damien Chaussabel YR 2020 UL http://biorxiv.org/content/early/2020/02/25/2020.02.24.962621.abstract AB Background Transcriptome profiling approaches have been widely used in the investigation of mechanisms underlying psoriasis pathogenesis. In most instances, changes in transcript abundance have been measured in skin biopsies. Fewer studies have examined changes in the blood samples from patients with psoriasis. While changes in the periphery may be less relevant, the blood cell transcriptome analysis presents the distinct advantage of being amenable to comparison across diseases.Methods Two public psoriasis blood transcriptome datasets were reanalyzed and compared against reference datasets encompassing 16 immune states and pathologies, employing a recently established modular repertoire framework.Results Although perturbations in psoriasis were relatively subtle in comparison to other auto-immune or auto-inflammatory diseases, consistent changes were observed for a signature associated with neutrophil activation/inflammation. This transcriptional signature most resembled that of subjects with Kawasaki disease.Conclusions The similarities observed between psoriasis and Kawasaki disease blood transcriptome signatures suggest that immune mechanisms driving the pathogenesis of these diseases may be at least partially shared. This notion is reinforced by case reports describing the development of psoriasis disease in patients with Kawasaki disease. Potential implications for novel therapeutic approaches, including the repurposing of biologic drugs targeting IL17 or its receptor for the treatment of Kawasaki disease are discussed.