@article {Casto2020.02.25.965426, author = {Amanda M. Casto and Meei-Li Huang and Hong Xie and Keith R. Jerome and Anna Wald and Christine Johnston and Alexander L. Greninger}, title = {Herpes Simplex Virus Mistyping due to HSV-1 x HSV-2 Interspecies Recombination in Viral Gene Encoding Glycoprotein B}, elocation-id = {2020.02.25.965426}, year = {2020}, doi = {10.1101/2020.02.25.965426}, publisher = {Cold Spring Harbor Laboratory}, abstract = {Human herpes simplex viruses (HSV) 1 and 2 are most often typed via molecular assays. Here we describe the first known case of HSV mistyping due to a previously undescribed HSV-1 x HSV-2 recombination event in UL27, the gene that encodes glycoprotein B. This is the first reported HSV interspecies recombination event impacting this gene, which is frequently used as a target for diagnostics and experimental therapeutics.}, URL = {https://www.biorxiv.org/content/early/2020/02/26/2020.02.25.965426}, eprint = {https://www.biorxiv.org/content/early/2020/02/26/2020.02.25.965426.full.pdf}, journal = {bioRxiv} }