RT Journal Article
SR Electronic
T1 Evidence for modulation of EEG microstate sequence by vigilance level
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.02.26.966150
DO 10.1101/2020.02.26.966150
A1 Marina Krylova
A1 Sarah Alizadeh
A1 Igor Izyurov
A1 Vanessa Teckentrup
A1 Catie Chang
A1 Johan van der Meer
A1 Michael Erb
A1 Nils Kroemer
A1 Thomas Koenig
A1 Martin Walter
A1 Hamidreza Jamalabadi
YR 2020
UL http://biorxiv.org/content/early/2020/02/27/2020.02.26.966150.abstract
AB The momentary global functional state of the brain is reflected in its electric field configuration and cluster analytical approaches have consistently shown four configurations, referred to as EEG microstate classes A to D. Changes in microstate parameters are associated with a number of neuropsychiatric disorders, task performance, and mental state establishing their relevance for cognition. However, the common practice to use eye-closed resting state data to assess the temporal dynamics of microstate parameters might induce systematic confounds related to vigilance levels. Here, we studied the dynamics of microstate parameters in two independent data sets and showed that the parameters of microstates are strongly associated with vigilance level assessed both by EEG power analysis and fMRI global signal. We found that the duration and contribution of microstate class C, as well as transition probabilities towards microstate class C were positively associated with vigilance, whereas the sign was reversed for microstate classes A and B. Furthermore, in looking for the origins of the correspondence between microstates and vigilance level, we found Granger-causal effects of vigilance levels on microstate sequence parameters. Collectively, our findings suggest that duration and occurrence of microstates have a different origin and possibly reflect different physiological processes. Finally, our findings indicate the need for taking vigilance levels into consideration in resting-sate EEG investigations.