TY - JOUR T1 - Transection of the ventral hippocampal commissure impairs spatial reference but not contextual or spatial working memory JF - bioRxiv DO - 10.1101/437491 SP - 437491 AU - Jake T. Jordan AU - Yi Tong AU - Carolyn L. Pytte Y1 - 2020/01/01 UR - http://biorxiv.org/content/early/2020/02/28/437491.abstract N2 - Plasticity is a neural phenomenon in which experience induces long-lasting changes to neuronal circuits and is at the center of most neurobiological theories of learning and memory. However, too much plasticity is maladaptive and must be balanced with substrate stability. Area CA3 of the hippocampus is lateralized with the left hemisphere dominant in plasticity and the right specialized for stability. Left and right CA3 project bilaterally to CA1; however, it is not known whether this downstream merging of lateralized plasticity and stability is functional. We hypothesized that interhemispheric integration of input from these pathways is essential for integrating spatial memory stored in the left CA3 with spatial working memory facilitated by the right CA3. To test this, we severed interhemispheric connections between the left and right hippocampi in mice and assessed learning and memory. Despite damage to this major hippocampal fiber tract, hippocampus-dependent spatial working memory and short- and long-term memory were both spared. However, tasks that required the integration of information retrieved from memory with ongoing spatial working memory and navigation were impaired. We propose that one function of interhemispheric communication in the mouse hippocampus is to integrate lateralized processing of plastic and stable circuits to facilitate memory-guided spatial navigation. ER -