PT  - JOURNAL ARTICLE
AU  - Linlin Bao
AU  - Wei Deng
AU  - Baoying Huang
AU  - Hong Gao
AU  - Jiangning Liu
AU  - Lili Ren
AU  - Qiang Wei
AU  - Pin Yu
AU  - Yanfeng Xu
AU  - Feifei Qi
AU  - Yajin Qu
AU  - Fengdi Li
AU  - Qi Lv
AU  - Wenling Wang
AU  - Jing Xue
AU  - Shuran Gong
AU  - Mingya Liu
AU  - Guanpeng Wang
AU  - Shunyi Wang
AU  - Zhiqi Song
AU  - Linna Zhao
AU  - Peipei Liu
AU  - Li Zhao
AU  - Fei Ye
AU  - Huijuan Wang
AU  - Weimin Zhou
AU  - Na Zhu
AU  - Wei Zhen
AU  - Haisheng Yu
AU  - Xiaojuan Zhang
AU  - Li Guo
AU  - Lan Chen
AU  - Conghui Wang
AU  - Ying Wang
AU  - Xinming Wang
AU  - Yan Xiao
AU  - Qiangming Sun
AU  - Hongqi Liu
AU  - Fanli Zhu
AU  - Chunxia Ma
AU  - Lingmei Yan
AU  - Mengli Yang
AU  - Jun Han
AU  - Wenbo Xu
AU  - Wenjie Tan
AU  - Xiaozhong Peng
AU  - Qi Jin
AU  - Guizhen Wu
AU  - Chuan Qin
TI  - The Pathogenicity of SARS-CoV-2 in hACE2 Transgenic Mice
AID  - 10.1101/2020.02.07.939389
DP  - 2020 Jan 01
TA  - bioRxiv
PG  - 2020.02.07.939389
4099  - http://biorxiv.org/content/early/2020/02/28/2020.02.07.939389.short
4100  - http://biorxiv.org/content/early/2020/02/28/2020.02.07.939389.full
AB  - Severe acute respiratory syndrome CoV-2 (SARS-CoV-2) caused the Corona Virus Disease 2019 (COVID-19) cases in China has become a public health emergency of international concern (PHEIC). Based on angiotensin converting enzyme 2 (ACE2) as cell entry receptor of SARS-CoV, we used the hACE2 transgenic mice infected with SARS-CoV-2 to study the pathogenicity of the virus. Weight loss and virus replication in lung were observed in hACE2 mice infected with SARS-CoV-2. The typical histopathology was interstitial pneumonia with infiltration of significant lymphocytes and monocytes in alveolar interstitium, and accumulation of macrophages in alveolar cavities. Viral antigens were observed in the bronchial epithelial cells, alveolar macrophages and alveolar epithelia. The phenomenon was not found in wild type mice with SARS-CoV-2 infection. The pathogenicity of SARS-CoV-2 in hACE2 mice was clarified and the Koch’s postulates were fulfilled as well, and the mouse model may facilitate the development of therapeutics and vaccines against SARS-CoV-2.