RT Journal Article
SR Electronic
T1 Structural attributes and principles of the neocortical connectome in the marmoset monkey
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.02.28.969824
DO 10.1101/2020.02.28.969824
A1 Panagiota Theodoni
A1 Piotr Majka
A1 David H. Reser
A1 Daniel K. Wójcik
A1 Marcello G.P. Rosa
A1 Xiao-Jing Wang
YR 2020
UL http://biorxiv.org/content/early/2020/03/02/2020.02.28.969824.abstract
AB The marmoset monkey has become an important primate model in Neuroscience. Here we characterize salient statistical properties of inter-areal connections of the marmoset cerebral cortex, using data from retrograde tracer injections. We found that the connectivity weights are highly heterogeneous, spanning five orders of magnitude, and are log-normally distributed. The cortico-cortical network is dense, heterogeneous and has high specificity. The reciprocal connections are the most prominent and the probability of connection between two areas decays with their functional dissimilarity. The laminar dependence of connections defines a hierarchical network correlated with microstructural properties of each area. The marmoset connectome reveals parallel streams associated with different sensory systems. Finally, the connectome is spatially embedded with a characteristic length that obeys a power law as a function of brain volume across species. These findings provide a connectomic basis for investigations of multiple interacting areas in a complex large-scale cortical system underlying cognitive processes.