TY - JOUR T1 - A little walk from physical to biological complexity: protein folding and stability JF - bioRxiv DO - 10.1101/043737 SP - 043737 AU - Fabrizio Pucci AU - Marianne Rooman Y1 - 2016/01/01 UR - http://biorxiv.org/content/early/2016/03/15/043737.abstract N2 - As an example of topic where biology and physics meet, we present the issue of protein folding and stability, and the development of thermodynamics-based bioinformatics tools that predict the stability and thermal resistance of proteins and the change of these quantities upon amino acid substitutions. These methods are based on knowledge-driven statistical potentials, derived from experimental protein structures using the inverse Boltzmann law. We also describe an application of these predictors, which contributed to the understanding of the mechanisms of aggregation of a particular protein known to cause a neuronal disease. ER -