RT Journal Article
SR Electronic
T1 Temporal learning among prefrontal and striatal ensembles
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.02.28.970053
DO 10.1101/2020.02.28.970053
A1 Emmons, Eric
A1 Tunes-Chiuffa, Gabriela
A1 Choi, Jeeyu
A1 Bruce, R. Austin
A1 Weber, Matthew A.
A1 Kim, Youngcho
A1 Narayanan, Nandakumar S.
YR 2020
UL http://biorxiv.org/content/early/2020/03/06/2020.02.28.970053.abstract
AB Behavioral flexibility requires the prefrontal cortex and striatum. Here, we investigate neuronal ensembles in the medial frontal cortex (MFC) and the dorsomedial striatum (DMS) during one form of behavioral flexibility: learning a new temporal interval. We studied corticostriatal neuronal activity as rodents trained to respond after a 12-second fixed interval (FI12) learned to respond at a shorter 3-second fixed interval (FI3). On FI12 trials, we discovered time-related ramping was reduced in the MFC but not in the DMS in two-interval vs. one-interval sessions. We also found that more DMS neurons than MFC neurons exhibited differential interval-related activity on the first day of two-interval performance. Finally, MFC and DMS ramping was similar with successive days of two-interval performance but DMS temporal decoding increased on FI3 trials. These data suggest that the MFC and DMS play distinct roles during temporal learning and provide insight into corticostriatal circuits.