RT Journal Article
SR Electronic
T1 Training deep neural density estimators to identify mechanistic models of neural dynamics
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 838383
DO 10.1101/838383
A1 Pedro J. Gonçalves
A1 Jan-Matthis Lueckmann
A1 Michael Deistler
A1 Marcel Nonnenmacher
A1 Kaan Öcal
A1 Giacomo Bassetto
A1 Chaitanya Chintaluri
A1 William F. Podlaski
A1 Sara A. Haddad
A1 Tim P. Vogels
A1 David S. Greenberg
A1 Jakob H. Macke
YR 2020
UL http://biorxiv.org/content/early/2020/03/07/838383.abstract
AB Mechanistic modeling in neuroscience aims to explain observed phenomena in terms of underlying causes. However, determining which model parameters agree with complex and stochastic neural data presents a significant challenge. We address this challenge with a machine learning tool which uses deep neural density estimators— trained using model simulations— to carry out Bayesian inference and retrieve the full space of parameters compatible with raw data or selected data features. Our method is scalable in parameters and data features, and can rapidly analyze new data after initial training. We demonstrate the power and flexibility of our approach on receptive fields, ion channels, and Hodgkin–Huxley models. We also characterize the space of circuit configurations giving rise to rhythmic activity in the crustacean stomatogastric ganglion, and use these results to derive hypotheses for underlying compensation mechanisms. Our approach will help close the gap between data-driven and theory-driven models of neural dynamics.