RT Journal Article
SR Electronic
T1 Hierarchical composition of reliable recombinase logic devices
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 390823
DO 10.1101/390823
A1 Sarah Guiziou
A1 Pauline Mayonove
A1 Jerome Bonnet
YR 2018
UL http://biorxiv.org/content/early/2018/08/13/390823.abstract
AB We provide a systematic framework for engineering reliable recombinase logic devices by hierarchical composition of well-characterized, optimized recombinase switches. We apply this framework to build a recombinase logic device family supporting up to 4-input Boolean logic. This work will support the predictable engineering of several classes of recombinase devices to reliably control cellular behavior.