RT Journal Article
SR Electronic
T1 Genomic analysis of European <em>Drosophila melanogaster</em> populations reveals longitudinal structure, continent-wide selection, and previously unknown DNA viruses
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 313759
DO 10.1101/313759
A1 Martin Kapun
A1 Maite G. Barrón
A1 Fabian Staubach
A1 Darren J. Obbard
A1 R. Axel W. Wiberg
A1 Jorge Vieira
A1 Clément Goubert
A1 Omar Rota-Stabelli
A1 Maaria Kankare
A1 María Bogaerts-Márquez
A1 Annabelle Haudry
A1 Lena Waidele
A1 Iryna Kozeretska
A1 Elena G. Pasyukova
A1 Volker Loeschcke
A1 Marta Pascual
A1 Cristina P. Vieira
A1 Svitlana Serga
A1 Catherine Montchamp-Moreau
A1 Jessica Abbott
A1 Patricia Gibert
A1 Damiano Porcelli
A1 Nico Posnien
A1 Alejandro Sánchez-Gracia
A1 Sonja Grath
A1 Élio Sucena
A1 Alan O. Bergland
A1 Maria Pilar Garcia Guerreiro
A1 Banu Sebnem Onder
A1 Eliza Argyridou
A1 Lain Guio
A1 Mads Fristrup Schou
A1 Bart Deplancke
A1 Cristina Vieira
A1 Michael G. Ritchie
A1 Bas J. Zwaan
A1 Eran Tauber
A1 Dorcas J. Orengo
A1 Eva Puerma
A1 Montserrat Aguadé
A1 Paul S. Schmidt
A1 John Parsch
A1 Andrea J. Betancourt
A1 Thomas Flatt
A1 Josefa González
YR 2020
UL http://biorxiv.org/content/early/2020/03/11/313759.abstract
AB Genetic variation is the fuel of evolution, with standing genetic variation especially important for short-term evolution and local adaptation. To date, studies of spatio-temporal patterns of genetic variation in natural populations have been challenging, as comprehensive sampling is logistically difficult, and sequencing of entire populations costly. Here, we address these issues using a collaborative approach, sequencing 48 pooled population samples from 32 locations, and perform the first continent-wide genomic analysis of genetic variation in European Drosophila melanogaster. Our analyses uncover longitudinal population structure, provide evidence for continent-wide selective sweeps, identify candidate genes for local climate adaptation, and document clines in chromosomal inversion and transposable element frequencies. We also characterise variation among populations in the composition of the fly microbiome, and identify five new DNA viruses in our samples.