TY - JOUR T1 - Bounded Rationality in <em>C. elegans</em> JF - bioRxiv DO - 10.1101/257535 SP - 257535 AU - Dror Cohen AU - Meshi Volovich AU - Yoav Zeevi AU - Lilach Elbaum AU - Kenway Louie AU - Dino J Levy AU - Oded Rechavi Y1 - 2018/01/01 UR - http://biorxiv.org/content/early/2018/08/16/257535.abstract N2 - Rational choice theory assumes optimality in decision-making. Violations of a basic axiom of economic rationality known as “Independence of Irrelevant Alternatives” (IIA), have been demonstrated in both humans and animals, and could stem from common neuronal constraints. We developed tests for IIA in the nematode Caenorhabditis elegans, an animal with only 302 neurons, using olfactory chemotaxis assays. We found that in most cases C. elegans make rational decisions. However, by probing multiple neuronal architectures using various choice sets, we show that asymmetric sensation of odor options by the AWCON neuron can lead to violations of rationality. We further show that genetic manipulations of the asymmetry between the AWC neurons can make the worm rational or irrational. Last, a normalization-based model of value coding and gain control explains how particular neuronal constraints on information coding give rise to irrationality. Thus, we demonstrate that bounded rationality could arise due to basic neuronal constraints. ER -