RT Journal Article
SR Electronic
T1 Gamma activity accelerates during prefrontal development
JF bioRxiv
FD Cold Spring Harbor Laboratory
SP 2020.03.10.986281
DO 10.1101/2020.03.10.986281
A1 Sebastian H. Bitzenhofer
A1 Jastyn A. Pöpplau
A1 Ileana L. Hanganu-Opatz
YR 2020
UL http://biorxiv.org/content/early/2020/03/11/2020.03.10.986281.abstract
AB Gamma oscillations are a prominent activity pattern in the cerebral cortex. While gamma rhythms have been extensively studied in the adult prefrontal cortex in the context of cognitive (dys)functions, little is known about their development. We addressed this issue by using extracellular recordings and optogenetic stimulations in mice across postnatal development. We show that fast rhythmic activity in the prefrontal cortex becomes prominent during the second postnatal week. While initially at about 15 Hz, fast oscillatory activity progressively accelerates with age and stabilizes within gamma frequency range (30-80 Hz) during the fourth postnatal week. Activation of layer 2/3 pyramidal neurons drives fast oscillations throughout development, yet the acceleration of their frequency follows similar temporal dynamics as the maturation of fast-spiking interneurons. These findings uncover the development of prefrontal gamma activity and provide a framework to examine the origin of abnormal gamma activity in neurodevelopmental disorders.