PT  - JOURNAL ARTICLE
AU  - Ream Al-Hasanil
AU  - Jenny-Marie T. Wong
AU  - Omar S. Mabrouk
AU  - Jordan G. McCall
AU  - Gavin P. Schmitz
AU  - Kirsten A. Porter-Stransky
AU  - Brandon J. Aragona
AU  - Robert T. Kennedy
AU  - Michael R. Bruchas
TI  - In vivo detection of optically-evoked opioid peptide release
AID  - 10.1101/393603
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 393603
4099  - http://biorxiv.org/content/early/2018/08/16/393603.short
4100  - http://biorxiv.org/content/early/2018/08/16/393603.full
AB  - Though the last decade has seen accelerated advances in techniques and technologies to perturb neuronal circuitry in the brain, we are still poorly equipped to adequately dissect endogenous peptide release in vivo. To this end we developed a system that combines in vivo optogenetics with microdialysis and a highly sensitive mass spectrometry-based assay to measure opioid peptide release in freely moving rodents.