PT  - JOURNAL ARTICLE
AU  - Arthur Charles-Orszag
AU  - Feng-Ching Tsai
AU  - Daria Bonazzi
AU  - Valeria Manriquez
AU  - Martin Sachse
AU  - Adeline Mallet
AU  - Audrey Salles
AU  - Keira Melican
AU  - Ralitza Staneva
AU  - Aurélie Bertin
AU  - Corinne Millien
AU  - Sylvie Goussard
AU  - Pierre Lafaye
AU  - Spencer Shorte
AU  - Matthieu Piel
AU  - Jacomine Krijnse-Locker
AU  - Françoise Brochard-Wyart
AU  - Patricia Bassereau
AU  - Guillaume Duménil
TI  - Adhesion to nanofibers drives cell membrane remodeling through 1D wetting
AID  - 10.1101/393744
DP  - 2018 Jan 01
TA  - bioRxiv
PG  - 393744
4099  - http://biorxiv.org/content/early/2018/08/16/393744.short
4100  - http://biorxiv.org/content/early/2018/08/16/393744.full
AB  - The shape of cellular membranes is highly regulated by a set of conserved mechanisms. These mechanisms can be manipulated by bacterial pathogens to infect cells. Human endothelial cell plasma membrane remodeling by the bacterium Neisseria meningitidis is thought to be essential during the blood phase of meningococcal infection, but the underlying mechanisms are unknown. Here we show that plasma membrane remodeling occurs independently of F-actin, along meningococcal type IV pili fibers, by a novel physical mechanism we term “ onedimensional” membrane wetting. We provide a theoretical model that gives the physical basis of 1D wetting and show that this mechanism occurs in model membranes interacting with model nanofibers, and in human cells interacting with model extracellular matrices. It is thus a new general principle driving the interaction of cells with their environment at the nanoscale that is diverted by meningococcus during infection.